Clinical, Radiologic, and Endoscopic Manifestations of Small Bowel Malignancies: a First Report from Thailand
Open Access
- 11 January 2016
- journal article
- Published by Asian Pacific Organization for Cancer Prevention in Asian Pacific Journal of Cancer Prevention
- Vol. 16 (18), 8613-8618
- https://doi.org/10.7314/apjcp.2015.16.18.8613
Abstract
Clinical, Radiologic, and Endoscopic Manifestations of Small Bowel Malignancies: a First Report from Thailand Small bowel cancer;GIST;adenocarcinoma;lymphoma;metastasis;radiologic manifestation; Background: The symptoms of small bowel malignancies are mild and frequently nonspecific, thus patients are often not diagnosed until the disease is at an advanced stage. Moreover, the lack of sufficient studies and available data on small bowel cancer makes diagnosis difficult, further delaying proper treatment for these patients. In fact, only a small number of published studies exist, and there are no studies specific to Thailand. Radiologic and endoscopic studies and findings may allow physicians to better understand the disease, leading to earlier diagnosis and improved patient outcomes. Objective: To retrospectively analyze the clinical, radiologic, and endoscopic characteristics of small bowel cancer patients in Thailand's Siriraj Hospital. Materials and Methods: This retrospective analysis included 185 adult patients (97 men, 88 women; mean age = $57.6{\pm}14.9$) with pathologically confirmed small bowel cancer diagnosed between January 2006 and December 2013. Clinical, radiologic, and endoscopic findings were collected and compared between each subtype of small bowel cancer. Results: Of the 185 patients analyzed, gastrointestinal stromal tumor (GIST) was the most common diagnosis (39.5%, n=73). Adenocarcinoma was the second most common (25.9%, n = 48), while lymphoma and all other types were identified in 24.3% (n = 45) and 10.3% (n = 19) of cases, respectively. The most common symptoms were weight loss (43.2%), abdominal pain (38.4%), and upper gastrointestinal bleeding (23.8%). Conclusions: Based on radiology and endoscopy, this study revealed upper gastrointestinal bleeding, an intra-abdominal mass, and a sub-epithelial mass as common symptoms of GIST. Obstruction and ulcerating/circumferential masses were findicative of adenocarcinoma, as revealed by radiology and endoscopy, respectively. Finally, no specific symptoms were related to lymphoma.This publication has 19 references indexed in Scilit:
- An obscure cause of gastrointestinal bleeding: Renal cell carcinoma metastasis to the small bowelInternational Journal of Surgery Case Reports, 2015
- Lifestyle factors and small intestine adenocarcinoma risk: A systematic review and meta-analysisCancer Epidemiology, 2015
- Gastrointestinal bleeding as presentation of small bowel metastases of malignant melanoma: Is surgery a good choice?International Journal of Surgery Case Reports, 2014
- Evaluation and management of small-bowel tumors in the era of deep enteroscopyGastrointestinal Endoscopy, 2014
- Small bowel adenocarcinoma and Crohn's disease: Any further ahead than 50 years ago?World Journal of Gastroenterology, 2014
- Small Bowel Cancer in the United StatesAnnals of Surgery, 2009
- Diagnosis and Outcome of Small Bowel Tumors Found by Capsule Endoscopy: A Three-Center Australian ExperienceThe American Journal of Gastroenterology, 2006
- Long‐term prognosis in Crohn's disease: factors that affect quality of lifeAlimentary Pharmacology & Therapeutics, 2006
- Incidence of Small Bowel Cancer in the United States and Worldwide: Geographic, Temporal, and Racial DifferencesCancer Causes & Control, 2005
- Radiology in primary small bowel adenocarcinomaAbdominal Radiology, 1980