Contraction‐associated translocation of protein kinase C in rat skeletal muscle
- 15 June 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 217 (2), 232-236
- https://doi.org/10.1016/0014-5793(87)80669-5
Abstract
Electrical stimulation of the sciatic nerve of the anaesthetized rat in vivo led to a time-dependent translocation of protein kinase C from the muscle cytosol to the particulate fraction. Maximum activity of protein kinase C in the particulate fraction occurred after 2 min of intermittent short tetanic contractions of the gastrocnemius-plantaris-soleus muscle group and coincided with the loss of activity from the cytosol. Translocation of protein kinase C may imply a role for this kinase in contraction-initiated changes in muscle metabolism.Keywords
This publication has 15 references indexed in Scilit:
- Inositol 1,4,5-trisphosphate enhances Ca2+-sensitivity of the contractile mechanism of chemically skinned rabbit skeletal muscle fibresBiochemical and Biophysical Research Communications, 1986
- Protein kinase C in cytosol and cell membranes of concanavalin A-stimulated rat thymocytesFEBS Letters, 1986
- Increased Muscle Glucose Uptake After Exercise: No Need for Insulin During ExerciseDiabetes, 1985
- Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle.Proceedings of the National Academy of Sciences of the United States of America, 1985
- Inositol 1,4,5-trisphosphate induces calcium release from sarcoplasmic reticulum of skeletal muscleNature, 1985
- Phosphorylation of the glucose transporter in vitro and in vivo by protein kinase CNature, 1985
- The role of protein kinase C in cell surface signal transduction and tumour promotionNature, 1984
- Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.Proceedings of the National Academy of Sciences of the United States of America, 1980
- Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase systemBiochemical and Biophysical Research Communications, 1979
- HINDLIMB MUSCLE FIBER POPULATIONS OF FIVE MAMMALSJournal of Histochemistry & Cytochemistry, 1973