Alpha-Toxin ofClostridium perfringensIs Not an Essential Virulence Factor in Necrotic Enteritis in Chickens
- 1 November 2006
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 74 (11), 6496-6500
- https://doi.org/10.1128/iai.00806-06
Abstract
The Clostridium perfringens alpha-toxin has previously been implicated as the major virulence factor in necrotic enteritis in chickens, although definitive proof has not been reported. In this study an alpha-toxin mutant was constructed in a virulent chicken isolate and shown to retain full virulence in a chicken disease model. These results demonstrated that alpha-toxin is not an essential virulence factor in the pathogenesis of necrotic enteritis in chickens.Keywords
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