Biochemical markers for non-invasive assessment of disease stage in patients with primary biliary cirrhosis
Open Access
- 1 January 2009
- journal article
- Published by Baishideng Publishing Group Inc. in World Journal of Gastroenterology
- Vol. 15 (5), 591-594
- https://doi.org/10.3748/wjg.15.591
Abstract
AIM: To evaluate different biochemical markers and their ratios in the assessment of primary biliary cirrhosis (PBC) stages. METHODS: This study included 112 patients with PBC who underwent a complete clinical investigation. We analyzed the correlation (Spearman's test) between ten biochemical markers and their ratios with different stages of PBC. The discriminative values were compared using areas under receiver operating characteristic (ROC) curves. RESULTS: The mean age of patients included in the study was 53.88 ± 10.59 years, including 104 females and 8 males. We found a statistically significant correlation between PBC stage and Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) to platelet ratio (APRI), ALT/platelet count, AST/ALT, ALT/AST and ALT/Cholesterol ratios, with the values of Spearman’s rho of 0.338, 0.476, 0.404, 0.356, 0.351 and 0.325, respectively. The best sensitivity and specificity was shown for AST/ALT, with an area under ROC of 0.660. CONCLUSION: Biochemical markers and their ratios do correlate with different sensitivity to and specificity of PBC disease stage. The use of biochemical markers and their ratios in clinical evaluation of PBC patients may reduce, but not eliminate, the need for liver biopsy.Keywords
This publication has 18 references indexed in Scilit:
- Non invasive fibrosis biomarkers reduce but not substitute the need for liver biopsyWorld Journal of Gastroenterology, 2006
- Primary Biliary CirrhosisNew England Journal of Medicine, 2005
- The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosisGastroenterology, 2005
- HIGH AST/ALT RATIO MAY INDICATE ADVANCED ALCOHOLIC LIVER DISEASE RATHER THAN HEAVY DRINKINGAlcohol and Alcoholism, 2004
- Primary biliary cirrhosis: Past, present, and futureGastroenterology, 2002
- Liver biopsy: complications and risk factorsWorld Journal of Gastroenterology, 2000
- Primary Biliary CirrhosisNew England Journal of Medicine, 1996
- Practice and complications of liver biopsyDigestive Diseases and Sciences, 1993
- Ratio of Serum Aspartate to Alanine Aminotransferase in Chronic Hepatitis Relationship to CirrhosisGastroenterology, 1988
- The Presentation and Diagnosis of 100 Patients with Primary Biliary CirrhosisNew England Journal of Medicine, 1973