Comparative study between effect of carbetocin and oxytocin on isoflurane-induced uterine hypotonia in twin pregnancy patients undergoing cesarean section
Open Access
- 1 January 2016
- journal article
- Published by Taylor & Francis Ltd in Egyptian Journal of Anaesthesia
- Vol. 32 (1), 117-121
- https://doi.org/10.1016/j.egja.2015.09.012
Abstract
BackgroundCarbetocin is a long acting structural analog of human oxytocin and is given as single IV bolus following the delivery; it is effective as an oxytocin infusion for several hours because the latter has a very short duration of action which requires a continuous infusion to achieve sustained uterotonic activity.Multiple pregnancy is one of the most common causes of postpartum hemorrhage. This study was done to compare the effect of carbetocin and oxytocin on uterine contraction and though the use of other uterotonic drugs postoperative in multiple pregnancy patients undergoing elective C.S.Patients and methodsSixty patients were enrolled in this study, and they were classified randomly into two groups: group C = received 100 μg carbetocin, group O = received 20 IU oxytocin. We compared between the two groups as regard hemodynamic parameters (heart rate and mean arterial blood pressure), uterine contraction, amount of blood loss and number of patients who needed to reduce isoflurane concentration.ResultsAs regards uterine contraction group O needed methylergometrine postoperative significantly more than group C and as regards blood loss; it was significantly decreased more in group C and though less reduction in blood pressure and less effect on heart rate than group O.ConclusionSingle dose of carbetocin appears to be more effective than oxytocin for several hours on uterine contraction and though preventing postpartum hemorrhage in multiple pregnancy patients undergoing elective caesarian section.Keywords
This publication has 16 references indexed in Scilit:
- Does carbetocin for prevention of postpartum haemorrhage at caesarean section provide clinical or financial benefit compared with oxytocin?Journal of Obstetrics and Gynaecology, 2011
- Haemodynamic effects of carbetocin and oxytocin given as intravenous bolus on women undergoing caesarean delivery: a randomised trialBJOG: An International Journal of Obstetrics and Gynaecology, 2011
- Carbetocin versus oxytocin for the prevention of postpartum haemorrhage following caesarean section: the results of a double‐blind randomised trialBJOG: An International Journal of Obstetrics and Gynaecology, 2010
- Trends in postpartum hemorrhage in high resource countries: a review and recommendations from the International Postpartum Hemorrhage Collaborative GroupBMC Pregnancy and Childbirth, 2009
- Utilization of carbetocin for prevention of postpartum hemorrhage after cesarean section: a randomized clinical trialArchiv für Gynäkologie, 2009
- Prevention of postpartum hemorrhage with misoprostolInternational Journal of Gynecology & Obstetrics, 2007
- Treatment for primary postpartum haemorrhage.Published by Wiley ,2007
- PIH6 ECONOMIC EVALUATION OF CARBETOCINE FOR THE PREVENTION OF UTERINE ATONY IN PATIENTS WITH RISK FACTORS IN MEXICOValue in Health, 2006
- Haemodynamic effects of oxytocin given as i.v. bolus or infusion on women undergoing Caesarean sectionBritish Journal of Anaesthesia, 2006
- Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocinEuropean Journal of Pharmacology, 2005