MR‐guided laser irradiation of recurrent glioblastomas
- 3 November 2005
- journal article
- case report
- Published by Wiley in Journal of Magnetic Resonance Imaging
- Vol. 22 (6), 799-803
- https://doi.org/10.1002/jmri.20446
Abstract
We treated two patients with recurrent glioblastoma multiforme using Nd:YAG laser irradiation in the framework of a salvage therapy. The underlying concept is to achieve cytoreduction by partial coagulation of the tumor. Magnetic resonance imaging (MRI) follow‐up examinations revealed a volume reduction of the laser‐irradiated areas, while the untreated parts of the tumor exhibited a progression. The survival time after the diagnosis of the recurrence was 16 and 20 months, respectively, which is substantially (about four times) longer than the natural history of the disease would suggest. In conclusion, cytoreduction by laser irradiation may be a promising option for patients suffering from recurrent glioblastoma multiforme. Future work should optimize the therapeutic regimen and evaluate this treatment approach in controlled clinical trials. J. Magn. Reson. Imaging 2005.Keywords
This publication has 17 references indexed in Scilit:
- Locoregional opening of the rodent blood–brain barrier for paclitaxel using Nd:YAG laser‐induced thermo therapy: A new concept of adjuvant glioma therapy?Lasers in Surgery and Medicine, 2003
- Signa SP/2 – A MRI System for Image Guided SurgeryMedical Laser Application, 2002
- In situ ablation of experimental liver metastases delays and reduces residual intrahepatic tumour growth and peritoneal tumour spread compared with hepatic resectionBritish Journal of Surgery, 2002
- An integrated visualization system for surgical planning and guidance using image fusion and an open MRJournal of Magnetic Resonance Imaging, 2001
- Permanent 125iodine implants for recurrent malignant gliomasInternational Journal of Radiation Oncology*Biology*Physics, 1999
- Computer-Assisted Intra-Operative Magnetic Resonance Imaging Monitoring of Interstitial Laser Therapy in the Brain: A Case ReportJournal of Biomedical Optics, 1998
- Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomasThe Lancet, 1995
- MRI-Guided Laser-Induced Interstitial Thermotherapy of Cerebral NeoplasmsJournal of Computer Assisted Tomography, 1994
- The Proton-Resonance-Frequency-Shift Method Compared with Molecular Diffusion for Quantitative Measurement of Two-Dimensional Time-Dependent Temperature Distribution in a PhantomJournal of Magnetic Resonance, Series B, 1994
- Selection bias, survival, and brachytherapy for gliomaJournal of Neurosurgery, 1992