Frequent EGFR Positivity and Overexpression in High-Grade Areas of Human MPNSTs
Open Access
- 1 January 2008
- journal article
- research article
- Published by Hindawi Limited in Sarcoma
- Vol. 2008, 1-7
- https://doi.org/10.1155/2008/849156
Abstract
Malignant peripheral nerve sheath tumours (MPNSTs) are highly malignant and resistant. Transformation might implicate up regulation of epidermal growth factor receptor (EGFR). Fifty-two MPNST samples were studied for EGFR, Ki-67, p53, and survivin expression by immunohistochemistry and forEGFRamplification by in situ hybridization. Results were correlated with clinical data.EGFRRNA was also quantified by RT-PCR in 20 other MPNSTs and 14 dermal neurofibromas. Half of the patients had a neurofibromatosis type 1 (NF1). EGFR expression, detected in 86% of MPNSTs, was more frequent in NF1 specimens and closely associated with high-grade and p53-positive areas. MPNSTs expressed moreEGFRtranscripts than neurofibromas. No amplification ofEGFRlocus was observed. NF1 status was the only prognostic factor in multivariate analysis, with median survivals of 18 and 43 months for patients with or without NF1. Finally, EGFR might become a new target for MPNSTs treatment, especially in NF1-associated MPNSTs.Keywords
Funding Information
- Centre Léon Bérard Cancer
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