The Son of sevenless Gene Product: a Putative Activator of Ras
- 31 January 1992
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 255 (5044), 603-606
- https://doi.org/10.1126/science.1736363
Abstract
The Son of sevenless (Sos) gene functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases. The Sos gene has now been isolated and sequenced. Its product is a 1595-amino acid protein similar to the CDC25 protein in Saccharomyces cerevisiae, a guanine nucleotide exchange factor that activates Ras. These results imply a role for the ras pathway in Drosophila neuronal development.Keywords
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