A study of the prebiotic-like effects of tomato juice consumption in rats with diet-induced non-alcoholic fatty liver disease (NAFLD)
- 9 August 2017
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Food & Function
- Vol. 8 (10), 3542-3552
- https://doi.org/10.1039/c7fo00393e
Abstract
Gut microbiota may play a role in the pathogenesis of NAFLD. We investigated whether tomato juice consumption for 5 weeks could ameliorate high-fat diet-induced alterations in certain intestinal bacterial groups and products arising from their metabolism (short-chain fatty acids and microbial phenolic catabolites). For this, we used a rat model with NAFLD induced by a high-fat diet, involving four experimental groups: NA (standard diet and water), NL (standard diet and tomato juice), HA (high-fat diet and water) and HL (high-fat diet and tomato juice). The onset of NAFLD impacted the gut microbiota profile, reducing the abundance of Bifidobacterium and Lactobacillus and increasing that of Enterobacteriaceae. Also, reduced concentrations of propionate, butyrate and phenolic catabolites and an increased acetate to propionate (Ac : Pr) ratio were observed. Tomato juice intake partially ameliorated high-fat diet-induced disturbances, particularly by increasing Lactobacillus abundance and diminishing the Ac : Pr ratio, suggesting a potential improvement of the metabolic pattern of NAFLD.Keywords
Funding Information
- Ministerio de Ciencia e Innovación (“Juan de la Cierva” Program)
- Ministerio de Economía y Competitividad (Projects BIO2012-38103 and Consolider Fun-C-Food C)
This publication has 53 references indexed in Scilit:
- Hypolipidemic Effect of Tomato Juice in Hamsters in High Cholesterol Diet-Induced HyperlipidemiaNutrients, 2015
- The effect of tomato juice supplementation on biomarkers and gene expression related to lipid metabolism in rats with induced hepatic steatosisEuropean Journal of Nutrition, 2014
- Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot studyThe American Journal of Clinical Nutrition, 2014
- Effects of a Lactobacillus paracasei B21060 based synbiotic on steatosis, insulin signaling and toll-like receptor expression in rats fed a high-fat dietThe Journal of Nutritional Biochemistry, 2014
- Lipid biomarkers and metabolic effects of lycopene from tomato juice on liver of rats with induced hepatic steatosisThe Journal of Nutritional Biochemistry, 2013
- Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So FarEvidence-Based Complementary and Alternative Medicine, 2013
- Gut Microbiota and Clinical Disease: Obesity and Nonalcoholic Fatty Liver DiseasePediatric Gastroenterology, Hepatology & Nutrition, 2013
- Antioxidant Bioactive Compounds in Selected Industrial Processing and Fresh Consumption Tomato CultivarsFood and Bioprocess Technology, 2011
- Influence of dietary supplementation with dextrin or oligofructose on the hepatic redox balance in ratsMolecular Nutrition & Food Research, 2011
- Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiotaResearch in Microbiology, 2006