The effects of carbohydrate ingestion during endurance running on post-exercise inflammation and hepcidin levels
- 16 September 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Journal of Applied Physiology
- Vol. 112 (5), 1889-1898
- https://doi.org/10.1007/s00421-011-2156-0
Abstract
The effect of carbohydrate (CHO) consumption during prolonged endurance running on post-exercise inflammation and hepcidin levels was investigated. Eleven well-trained male endurance athletes completed a graded exercise test, followed by two experimental running trials in a randomized order. The two experimental trials consisted of a 90 min run at 75% of the peak oxygen uptake velocity (vVO2peak), while consuming a solution with either 6% CHO or a placebo (PLA) equivalent at 3 ml kg−1 every 20 min. Serum interleukin-6 (IL-6), free hemoglobin (Hb), haptoglobin (Hp), hepcidin and iron parameters were assessed throughout the post-run recovery period. Serum iron and IL-6 were significantly elevated immediately post-run in both CHO and PLA (p ≤ 0.05), with no differences between trials. Serum-free Hb increased and Hp decreased significantly immediately post-run in both conditions (p ≤ 0.05). Serum soluble transferrin receptor levels were significantly below the baseline at 3 and 24 h post-run in both conditions (p ≤ 0.05). Serum hepcidin concentration recorded 3 h post-run in both conditions was significantly elevated (p ≤ 0.05), and had returned to the baseline by 24 h post-run (p ≤ 0.05). The use of a 6% CHO solution at 3 ml kg−1 20 min−1 during endurance running did not attenuate the inflammatory response and subsequent increase in serum hepcidin levels during the post-run recovery period.Keywords
This publication has 51 references indexed in Scilit:
- The effect of carbohydrate ingestion on plasma interleukin-6, hepcidin and iron concentrations following prolonged exerciseCytokine, 2011
- Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its InternalizationScience, 2004
- Fluid Replacement during Marathon RunningClinical Journal of Sport Medicine, 2003
- Erythropoietin resistance: the role of inflammation and pro‐inflammatory cytokinesNephrology Dialysis Transplantation, 2002
- Effects of exercise on soluble transferrin receptor and other variables of the iron statusBritish Journal of Sports Medicine, 2002
- Transcriptional activation of the IL‐6 gene in human contracting skeletal muscle: influence of muscle glycogen contentThe FASEB Journal, 2001
- Exercise and interleukin-6Current Opinion in Hematology, 2001
- A 1% treadmill grade most accurately reflects the energetic cost of outdoor runningJournal of Sports Sciences, 1996
- Etiology of gastrointestinal disturbances during endurance eventsScandinavian Journal of Medicine & Science in Sports, 1991
- Iron Particles in Normal Erythroblasts and Normal and Pathological ErythrocytesThe Journal of cell biology, 1957