Activation of NK Cells by ADCC Antibodies and HIV Disease Progression
- 1 October 2011
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in JAIDS Journal of Acquired Immune Deficiency Syndromes
- Vol. 58 (2), 127-131
- https://doi.org/10.1097/qai.0b013e31822c62b9
Abstract
Antibody-dependent cellular cytotoxicity (ADCC) is of considerable interest as an immune response that may facilitate the control of HIV infection. We studied ADCC responses prospectively in a cohort of 79 HIV-positive subjects followed up for a mean of 2.3 years without antiretroviral therapy. We used a novel assay of the ability of ADCC to activate natural killer (NK) cells, either from the same HIV-positive subject or from a healthy blood donor. We found that ADCC responses to either gp140 Env protein or HIV peptide pools were common in HIV-positive subjects when NK cells from the HIV-positive subject were used but did not correlate with markers of HIV disease progression. In contrast, ADCC responses to whole gp140 Env protein were strongly associated with a slower decline in CD4 T-cell loss when healthy donor NK cells were used as effectors. Our data had implications for induction of the most effective ADCC responses by HIV vaccines.Keywords
This publication has 18 references indexed in Scilit:
- An HIV-1 gp120 Envelope Human Monoclonal Antibody That Recognizes a C1 Conformational Epitope Mediates Potent Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity and Defines a Common ADCC Epitope in Human HIV-1 SerumJournal of Virology, 2011
- Immune escape from HIV-specific antibody-dependent cellular cytotoxicity (ADCC) pressureProceedings of the National Academy of Sciences of the United States of America, 2011
- Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in ThailandThe New England Journal of Medicine, 2009
- Robust NK Cell-Mediated Human Immunodeficiency Virus (HIV)-Specific Antibody-Dependent Responses in HIV-Infected SubjectsJournal of Virology, 2008
- Fc receptor but not complement binding is important in antibody protection against HIVNature, 2007
- NK cells in HIV infection: Paradigm for protection or targets for ambushNature Reviews Immunology, 2005
- Antibody-dependent cell-mediated cytotoxic responses in participants enrolled in a phase I/II ALVAC-HIV/AIDSVAX® B/E prime-boost HIV-1 vaccine trial in ThailandVaccine, 2005
- Women with Cervicovaginal Antibody‐Dependent Cell‐Mediated Cytotoxicity Have Lower Genital HIV‐1 RNA LoadsThe Journal of Infectious Diseases, 2004
- Innate Immunity in Human Immunodeficiency Virus Infection: Effect of Viremia on Natural Killer Cell FunctionThe Journal of Infectious Diseases, 2003
- Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytesNature, 2002