First isolation of two colistin-resistant emerging pathogens, Brevundimonas diminuta and Ochrobactrum anthropi, in a woman with cystic fibrosis: a case report

Abstract

Cystic fibrosis afflicted lungs support the growth of many bacteria rarely implicated in other cases of human infections. We report the isolation and identification, by 16S rRNA amplification and sequencing, of two emerging pathogens resistant to colistin, Brevundimonas diminuta and Ochrobactrum anthropi, in a 17-year-old woman with cystic fibrosis and pneumonia. The patient eventually responded well to a 2-week regime of imipenem and tobramycin. Our results clearly re-emphasize the emergence of new colistin-resistant pathogens in patients with cystic fibrosis.