Temporal variability in the allergenicity of airborneAlternariaspores
Open Access
- 12 September 2018
- journal article
- research article
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 57 (4), 403-411
- https://doi.org/10.1093/mmy/myy069
Abstract
The concentration of fungal spores in the air is traditionally considered as a proxy of allergen exposure. However, in vitro experiments have shown that the allergenicity of Alternaria spores varies depending on ecophysiological and developmental factors. Despite the potential clinical significance of these findings, it has never been verified in outdoor environments. This study, therefore, aims to investigate variability in the amount of the major allergen (Alt a 1) released from Alternaria spores in outdoor air. During the 3-year monitoring study (2014–2016), the median seasonal allergenicity of Alternaria spores exceeded 8.6 × 10−3 pg Alt a 1/spore. The most allergenic spores were collected during the driest and the most polluted season (with respect to seasonal concentrations of ozone, sulphur dioxide, and particulate matter). Within the season, daily spore allergenicity ranged from 2.4 to 34.7 × 10−3 pg Alt a 1/spore (5th-95th percentile). No repeatable effects of weather and pollution on short-term variations in Alternaria spore allergenicity were found. However, during the episodes when high-potency spores were recorded, the air masses arrived from eastern directions. Contrary, the spores with the lowest allergenicity were related to western winds. This suggests that factors such as source area (habitat types) and species diversity could be responsible for the varying exposure to Alternaria allergens. Our findings show that high and low-potency spores are recorded in the air; therefore, the airborne concentrations of fungal spores alone may not be sufficient to provide allergy sufferers and healthcare professionals with information about allergen exposure.Keywords
Funding Information
- Polish National Science Centre (2013/09/D/NZ7/003588)
- RNA Research Centre (01/KNOW2/2014)
This publication has 47 references indexed in Scilit:
- Alternaria redefinedStudies in Mycology, 2013
- The influence of sensitisation to pollens and moulds on seasonal variations in asthma attacksEuropean Respiratory Journal, 2013
- Elevated Atmospheric Carbon Dioxide Concentrations Amplify Alternaria alternata Sporulation and Total Antigen ProductionEnvironmental Health Perspectives, 2010
- A method for producing airborne pollen source inventories: An example of Ambrosia (ragweed) on the Pannonian PlainAgricultural and Forest Meteorology, 2010
- Analyses of air samples for ascospores ofLeptosphaeria maculans andL.biglobosa by light microscopy and molecular techniquesJournal of Applied Genetics, 2009
- Alternaria infections: laboratory diagnosis and relevant clinical featuresClinical Microbiology & Infection, 2008
- Comparison of outdoor allergenic particles and allergen levelsAnnals of Allergy, Asthma & Immunology, 2000
- The effect of outdoor fungal spore concentrations on daily asthma severity.Environmental Health Perspectives, 1997
- Immunochemical quantitation of airborne short ragweed, Alternaria, antigen E, and Alt-I allergens: a two-year prospective studyJournal of Allergy and Clinical Immunology, 1983
- Changes in atmospheric spore content: Diurnal periodicity and the effects of weatherTransactions of the British Mycological Society, 1953