Potentiating effect of ribavirin on the anti-retrovirus activity of 3′-azido-2,6-diaminopurine-2′,3′-dideoxyriboside in vitro and in vivo
- 30 June 1989
- journal article
- Published by Elsevier BV in Antiviral Research
- Vol. 11 (4), 161-171
- https://doi.org/10.1016/0166-3542(89)90001-6
Abstract
3′-Azido-2,6-diaminopurine-2′,3′-dideoxyriboside (AzddDAPR) is a potent and selective inhibitor of human immunodeficiency virus (HIV) replication in vitro. It also inhibits Moloney murine sarcoma virus (MSV)-induced transformation of murine C3H/3T3 embryo fibroblasts. AzddDAPR causes a marked dose-dependent suppression of MSV-induced tumor formation and mortality therewith associated in newborn mice infected with MSV. Combination of AzddDAPR with ribavirin resulted in a marked potentiation of its anti-retrovirus activity in vitro and a significant enhancement of its inhibitory effect on MSV-induced tumor formation in vivo. A slight increase in the in vivo toxicity of AzddDAPR was noted when combined with ribavirin.Keywords
This publication has 15 references indexed in Scilit:
- Estimation of the lipophilicity of anti-HIV nucleoside analogues by determination of the partition coefficient and retention time on a lichrospher 60 RP-8 HPLC columnBiochemical and Biophysical Research Communications, 1989
- Anti-retrovirus activity of 3′-fluoro- and 3′-azido-substituted pyrimidine 2′,3′-dideoxynucleoside analoguesBiochemical Pharmacology, 1988
- Initial studies on the cellular pharmacology of 2′,3′-dideoxyinosine, an inhibitor of HIV infectivityBiochemical Pharmacology, 1987
- Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitroAntimicrobial Agents and Chemotherapy, 1987
- Selective inhibition of human immunodeficiency virus (HIV) by 3′-Azido-2′,3′-dideoxyguanosine invitroBiochemical and Biophysical Research Communications, 1987
- Initial studies on the cellular pharmacology of 2',3'-dideoxyadenosine, an inhibitor of HTLV-III infectivityBiochemical Pharmacology, 1987
- The 2′,3′-dideoxyriboside of 2,6-diaminopurine selectively inhibits human immunodeficiency virus (HIV) replication invitroBiochemical and Biophysical Research Communications, 1987
- Synergistic inhibition of human T-cell lymphotropic virus type III replication in vitro by phosphonoformate and recombinant alpha-A interferonAntimicrobial Agents and Chemotherapy, 1986
- Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDSScience, 1984
- Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Science, 1983