The epidemiology of Takayasu arteritis in the UK
Open Access
- 19 June 2009
- journal article
- research article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 48 (8), 1008-1011
- https://doi.org/10.1093/rheumatology/kep153
Abstract
Objectives. Takayasu arteritis (TAK) is a large-vessel vasculitis of unknown aetiology. The annual incidence in hospital-based studies is 1–2/million. The UK General Practice Research Database (UKGPRD) contains complete primary care records on 3.6 million people. There are no data on the incidence of TAK in the UK or from primary care anywhere in the world. The aim of this study was to determine the annual incidence of TAK in the UK using the UKGPRD and in a well-defined hospital population [Norfolk Vasculitis Register (NORVASC)]. Methods. We identified all patients in the UKGPRD with a first diagnosis of TAK during 2000–05, using the Read code (G757); and in the NORVASC population. The annual incidence was calculated as the number of incident cases divided by total person-years. Results. A total of 14 (13 females) subjects were identified with a first diagnosis of TAK during 2000–05 in the UKGPRD. The median age was 51.0 years (interquartile range 28–66). The overall annual incidence of TAK was 0.8/million (95% CI 0.4, 1.3). The incidence was stable throughout the study period. The mean prevalence of TAK was 4.7/million. There were six patients (five females) aged Conclusion. This is the first population-based study of the epidemiology of TAK. The annual incidence and prevalence are consistent with previous studies.Keywords
This publication has 14 references indexed in Scilit:
- Systemic lupus erythematosus prevalence in the U.K.: methodological issues when using the General Practice Research Database to estimate frequency of chronic relapsing-remitting diseasePharmacoepidemiology and Drug Safety, 2006
- Incidence of diagnosed polymyalgia rheumatica and temporal arteritis in the United Kingdom, 1990-2001Annals Of The Rheumatic Diseases, 2006
- Incidence of clinically diagnosed systemic lupus erythematosus 1992-1998 using the UK General Practice Research DatabasePharmacoepidemiology and Drug Safety, 2006
- The relationship between time since registration and measured incidence rates in the General Practice Research DatabasePharmacoepidemiology and Drug Safety, 2005
- Stable incidence of primary systemic vasculitides over five years: Results from the German vasculitis registerArthritis Care & Research, 2005
- Incidence of primary systemic vasculitides in Vilnius: a university hospital population based studyAnnals Of The Rheumatic Diseases, 2005
- Validation of the diagnosis of venous thromboembolism in general practice database studiesBritish Journal of Clinical Pharmacology, 2000
- Epidemiology of systemic vasculitis: A ten-year study in the United KingdomArthritis & Rheumatism, 2000
- Use of the UK General Practice Research Database for pharmacoepidemiologyBritish Journal of Clinical Pharmacology, 1998
- The American College of Rheumatology 1990 criteria for the classification of takayasu arteritisArthritis & Rheumatism, 1990