Default Mode, Dorsal Attention and Auditory Resting State Networks Exhibit Differential Functional Connectivity in Tinnitus and Hearing Loss
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Open Access
- 2 October 2013
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 8 (10), e76488
- https://doi.org/10.1371/journal.pone.0076488
Abstract
We investigated auditory, dorsal attention, and default mode networks in adults with tinnitus and hearing loss in a resting state functional connectivity study. Data were obtained using continuous functional magnetic resonance imaging (fMRI) while the participants were at “rest” and were not performing any task. Participants belonged to one of three groups: middle-aged adults with tinnitus and mild-to-moderate high frequency hearing loss (TIN), age-matched controls with normal hearing and no tinnitus (NH), and a second control group with mild-to-moderate high frequency hearing loss without tinnitus (HL). After standard preprocessing, (a) a group independent component analysis (ICA) using 30 components and (b) a seeding-based connectivity analysis were conducted. In the group ICA, the default mode network was the only network to display visual differences between subject groups. In the seeding analysis, we found increased connectivity between the left parahippocampus and the auditory resting state network in the TIN group when compared to NH controls. Similarly, there was also an increased correlation between the right parahippocampus and the dorsal attention network when compared to HL controls. Other group differences in this attention network included decreased correlations between the seed regions and the right supramarginal gyrus in TIN patients when compared to HL controls. In the default mode network, there was a strong decrease in correlation between the seed regions and the precuneus when compared to both control groups. The findings of this study identify specific alterations in the connectivity of the default mode, dorsal attention, and auditory resting state networks due to tinnitus. The results suggest that therapies for tinnitus that mitigate the increased connectivity of limbic regions with auditory and attention resting state networks and the decreased coherence of the default mode network could be effective at reducing tinnitus-related distress.This publication has 52 references indexed in Scilit:
- Optimized Design and Analysis of Sparse-Sampling fMRI ExperimentsFrontiers in Neuroscience, 2013
- Plasticity of somatosensory inputs to the cochlear nucleus – Implications for tinnitusHearing Research, 2011
- Functional resting-state networks are differentially affected in schizophreniaSchizophrenia Research, 2011
- Brain Network Connectivity in Individuals with Schizophrenia and Their SiblingsBiological Psychiatry, 2011
- Lateral differences in the default mode network in healthy controls and patients with schizophreniaHuman Brain Mapping, 2011
- The neural correlates of tinnitus-related distressNeuroImage, 2010
- Default mode network abnormalities in bipolar disorder and schizophreniaPsychiatry Research: Neuroimaging, 2010
- Electrophysiological signatures of resting state networks in the human brainProceedings of the National Academy of Sciences of the United States of America, 2007
- Spontaneous Low-Frequency Fluctuations in the BOLD Signal in Schizophrenic Patients: Anomalies in the Default NetworkSchizophrenia Bulletin, 2007
- Spontaneous neuronal activity distinguishes human dorsal and ventral attention systemsProceedings of the National Academy of Sciences of the United States of America, 2006