Thyroid Cancer in the Pediatric Population
Top Cited Papers
Open Access
- 17 September 2019
- Vol. 10 (9), 723
- https://doi.org/10.3390/genes10090723
Abstract
Thyroid cancer is rare in the pediatric population, but thyroid carcinomas occurring in children carry a unique set of clinical, pathologic, and molecular characteristics. In comparison to adults, children more often present with aggressive, advanced stage disease. This is at least in part due to the underlying biologic and molecular differences between pediatric and adult thyroid cancer. Specifically, papillary thyroid carcinoma (which accounts for approximately 90% of pediatric thyroid cancer) has a high rate of gene fusions which influence the histologic subtypes encountered in pediatric thyroid tumors, are associated with more extensive extrathyroidal disease, and offer unique options for targeted medical therapies. Differences are also seen in pediatric follicular thyroid cancer, although there are few studies of non-papillary pediatric thyroid tumors published in the literature due to their rarity, and in medullary carcinoma, which is most frequently diagnosed in the pediatric population in the setting of prophylactic thyroidectomies for known multiple endocrine neoplasia syndromes. The overall shift in the spectrum of histotypes and underlying molecular alterations common in pediatric thyroid cancer is important to recognize as it may directly influence diagnostic test selection and therapeutic recommendations.Keywords
This publication has 133 references indexed in Scilit:
- Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancersJCI Insight, 2013
- Effect of patient Age on surgical outcomes for Graves’ disease: a case–control study of 100 consecutive patients at a high volume thyroid surgical centerInternational Journal of Pediatric Endocrinology, 2013
- Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III TrialJournal of Clinical Oncology, 2012
- RET/PTC Translocations and Clinico-Pathological Features in Human Papillary Thyroid CarcinomaFrontiers in Endocrinology, 2012
- Oncogenic Alterations in Papillary Thyroid Cancers of Young PatientsThyroid®, 2012
- Management of medullary thyroid carcinoma and MEN2 syndromes in childhoodNature Reviews Endocrinology, 2011
- Activity of XL184 (Cabozantinib), an Oral Tyrosine Kinase Inhibitor, in Patients With Medullary Thyroid CancerJournal of Clinical Oncology, 2011
- The Successful Use of Sorafenib to Treat Pediatric Papillary Thyroid CarcinomaThyroid®, 2009
- Expression of iodine metabolism genes in human thyroid tissues: evidence for age and BRAFV600E mutation dependencyClinical Endocrinology, 2009
- NTRK1 re-arrangement in papillary thyroid carcinomas of children after the Chernobyl reactor accidentInternational Journal of Cancer, 1999