The Genetic Landscape of a Cell
- 22 January 2010
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 327 (5964), 425-431
- https://doi.org/10.1126/science.1180823
Abstract
Making Connections: Genetic interaction profiles highlight cross-connections between bioprocesses, providing a global view of cellular pleiotropy, and enable the prediction of genetic network hubs. Costanzo et al. (p. 425 ) performed a pairwise fitness screen covering approximately one-third of all potential genetic interactions in yeast, examining 5.4 million gene-gene pairs and generating quantitative profiles for ∼75% of the genome. Of the pairwise interactions tested, about 3% of the genes investigated interact under the conditions tested. On the basis of these data, a reference map for the yeast genetic network was created.Keywords
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