Laboratory-based surveillance of current antimicrobial resistance patterns and trends among Staphylococcus aureus: 2005 status in the United States
Open Access
- 1 January 2006
- journal article
- research article
- Published by Springer Science and Business Media LLC in Annals of Clinical Microbiology and Antimicrobials
- Vol. 5 (1), 2
- https://doi.org/10.1186/1476-0711-5-2
Abstract
The virulence, antimicrobial resistance, and prevalence of S. aureus underscores the need for up-to-date and extensive insights regarding antimicrobial susceptibility trends. One approach to meet this need is analysis of clinical laboratory – based surveillance data. Data from The Surveillance Network-USA (TSN), an electronic surveillance network that collects microbiology data from 300 clinical microbiology laboratories across the United States, were used as the source for analysis that included prevalence of S. aureus in clinical specimens, MRSA and multi-drug resistance phenotype rates and trends according to patient location, geographic distributions, and specimen source. S. aureus was the most prevalent species isolated from inpatient specimens (18.7% of all bacterial isolates) and the second most prevalent (14.7%) from outpatient specimens. In March 2005 MRSA rates were 59.2%, 55%, and 47.9% for strains from non-ICU inpatients, ICU, and outpatients, respectively. This trend was noted in all nine US Bureau of Census regions and multi-drug resistance phenotypes (resistance to ≥ 3 non-beta-lactams) was common among both inpatient MRSA (59.9%) and outpatient MRSA (40.8%). Greater than 90% of multi-drug resistant MRSA were susceptible to trimethoprim-sulfamethoxazole, linezolid, and vancomycin. Prevalence of MRSA among both inpatient and outpatient specimens continues to increase with multi-drug resistance as a common phenotype. Continued emergence of outpatient MRSA that exhibit multi-drug resistant phenotypes has important implications for developing and evolving outpatient treatment guidelines.Keywords
This publication has 26 references indexed in Scilit:
- Severe Community-Onset Pneumonia in Healthy Adults Caused by Methicillin-Resistant Staphylococcus aureus Carrying the Panton-Valentine Leukocidin GenesClinical Infectious Diseases, 2005
- Antimicrobial Resistance to LinezolidClinical Infectious Diseases, 2004
- Origins of Community Strains of Methicillin-Resistant Staphylococcus aureusClinical Infectious Diseases, 2004
- Comparison of Community- and Health Care–Associated Methicillin-Resistant Staphylococcus aureus InfectionPublished by American Medical Association (AMA) ,2003
- Community-acquired methicillin-resistant Staphylococcus aureus: Epidemiology and potential virulence factorsCurrent Infectious Disease Reports, 2003
- Prevalence of Oxacillin Resistance in Staphylococcus aureus among Inpatients and Outpatients in the United States during 2000Antimicrobial Agents and Chemotherapy, 2002
- Survey of Infections Due toStaphylococcusSpecies: Frequency of Occurrence and Antimicrobial Susceptibility of Isolates Collected in the United States, Canada, Latin America, Europe, and the Western Pacific Region for the SENTRY Antimicrobial Surveillance Program, 1997–1999Clinical Infectious Diseases, 2001
- Involvement of Panton-Valentine Leukocidin--Producing Staphylococcus aureus in Primary Skin Infections and PneumoniaClinical Infectious Diseases, 1999
- Nosocomial Bloodstream Infections in United States Hospitals: A Three‐Year AnalysisClinical Infectious Diseases, 1999
- Surveillance of Antimicrobial Use and Antimicrobial Resistance in United States Hospitals: Project ICARE Phase 2Clinical Infectious Diseases, 1999