Human Pharmacology and Abuse Potential of the Analgesic Buprenorphine
- 1 April 1978
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 35 (4), 501-516
- https://doi.org/10.1001/archpsyc.1978.01770280111012
Abstract
• Buprenorphine was evaluated for its abuse potential and utility in treating narcotic addiction. The drug was morphine-like but was 25 to 50 times more potent than morphine and was longer-acting. Little if any physical dependence of clinical significance was produced by buprenorphine. The effects of morphine to 120-mg doses were blocked by buprenorphine, a blockade that persisted for 291/2 hours. In man, buprenorphine has less intrinsic activity than morphine, and as such, has a low abuse potential. Moreover, the drug has potential for treating narcotic addiction since it is acceptable to addicts, is long-acting, produces a low level of physical dependence such that patients may be easily detoxified, is less toxic than drugs used for maintenance therapy, and blocks the effects of narcotics.Keywords
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