Synthesis of Potential Biologically Active 1,2-Benzothiazin-3-yl-quinazolin-4(3H)-ones
Open Access
- 1 January 2006
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 54 (8), 1175-1178
- https://doi.org/10.1248/cpb.54.1175
Abstract
A series of potential biologically active 2-(4-hydroxy-1,1-dioxido-2H-1,2-benzothiazin-3-yl)quinazolin-4(3H)-ones was synthesized in a straight forward manner by condensation of respective 4-hydroxy-1,2-benzothiazine-1,1-dioxides with anthranilamide followed by simple and high throughput cyclization of N-[2-(aminocarbonyl)phenyl]-4-hydroxy-1,2-benzothiazine-3-carboxamide-1,1-dioxides. All the synthesized compounds were subjected to preliminary evaluation for their biological activity against Gram positive and Gram negative bacteria. Some of the assayed compounds showed marked activity against Bacillus subtilis.Keywords
This publication has 15 references indexed in Scilit:
- A Simple and Efficient Synthesis of Methyl 3,4-Dihydro-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide from Saccharin Sodium SaltSynthesis, 2006
- 1,2-Benzothiazine 1,1-dioxide α-ketoamide analogues as potent calpain I inhibitorsBioorganic & Medicinal Chemistry Letters, 2004
- 1,2-Benzothiazine 1,1-Dioxide P2−P3 Peptide Mimetic Aldehyde Calpain I InhibitorsJournal of Medicinal Chemistry, 2001
- Antifungal and Immunomodulating Activities of 1,4-Benzothiazine Azole Derivatives: ReviewJournal of Chemotherapy, 2001
- Interaction of Meloxicam with Cimetidine, Maalox, or AspirinThe Journal of Clinical Pharmacology, 1996
- Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerizationJournal of Medicinal Chemistry, 1990
- Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (Afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity.The Japanese Journal of Pharmacology, 1982
- Studies on biologically active halogenated compounds. 1. Synthesis and central nervous system depressant activity of 2-(fluoromethyl)-3-aryl-4(3H)-quinazolinone derivativesJournal of Medicinal Chemistry, 1979
- Antibacterial 2,3-dihydro-2-(5-nitro-2-thienyl)quinazolin-4-(1H)-onesJournal of Medicinal Chemistry, 1972
- Synthesis and antiinflammatory activity of some 3-carboxamides of 2-alkyl-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxideJournal of Medicinal Chemistry, 1971