Aldol-Type Reaction ofα-Halo Ketones withα-Ketocarboxylates Mediated by SmI2or SmI3: Facile Synthesis ofα-Hydroxy-γ-ketocarboxylates
- 1 December 1994
- journal article
- research article
- Published by Informa UK Limited in Synthetic Communications
- Vol. 24 (22), 3315-3319
- https://doi.org/10.1080/00397919408010255
Abstract
The title reaction smoothly proceeds at room temperature to give α-hydroxy-γ-keto esters 3 in good yields, probably via a mechanism involving samarium enolates formed in situ from α-halo ketones.Keywords
This publication has 2 references indexed in Scilit:
- Hydroperfluoroalkylation of alkenes using RfI/ YbCl3 (cat.) /Zn systemTetrahedron Letters, 1993
- An Aldol-Like Reaction Mediated by SmI2Synthetic Communications, 1988