ADRB3Polymorphism Associated with BMI Gain in Japanese Men
Open Access
- 8 April 2012
- journal article
- research article
- Published by Hindawi Limited in Experimental Diabetes Research
- Vol. 2012, 1-5
- https://doi.org/10.1155/2012/973561
Abstract
Objective. The aim of this study was to evaluate the association between the Trp64Arg polymorphism in the beta3-adrenergic receptor gene (ADRB3: rs4994) and BMI and serological and anthropometric data in healthy Japanese. Methods. Healthy Japanese recruited in a large-scale integrated manufacturing facility in Japan (𝑁=1355; age: 37.25 ± 9.43; BMI: 22.86 ± 3.46) were eligible for analysis. The anthropometric data and serological data were measured during a comprehensive health check, and a self-reporting questionnaire was used to assess lifestyle habits (current exercise, smoking status, alcohol intake, and working style) and weight at age 20. Genotyping for the ADRB3 polymorphism was performed by PCR-RFLP method. Results. Among 1355 participants, the genotype frequencies of the Trp/Trp, Trp/Arg, and Arg/Arg variants were 920 (67.9%), 394 (29.1%), and 41 (3.05%), respectively. In the multivariate analysis, a multiple linear regression model in men for the adjustment of age, drinking habits, smoking habits, exercise habits, working status and serological measurements statistically showed an overall weak significance between annual BMI gain from age 20 and age, LDL or ADRB3 polymorphism. Conclusions. The level of LDL, age, and ADRB3 polymorphism (Arg/Arg genotype) were statistically associated with annual BMI gain in Japanese men.Keywords
This publication has 30 references indexed in Scilit:
- Effect of the β3-adrenergic receptor gene polymorphism Trp64Arg on BMI reduction associated with an exercise-based intervention program in Japanese middle-aged malesEnvironmental Health and Preventive Medicine, 2010
- Trends in the prevalence of obesity and overweight in English adults by age and birth cohort, 1991–2006Public Health Nutrition, 2010
- Relationship Between Obesity and Incident Diabetes in Middle-Aged and Older Japanese Adults: The Ibaraki Prefectural Health StudyMayo Clinic Proceedings, 2010
- Trp64Arg Polymorphism in Beta3-Adrenergic Receptor Gene Is Associated with Decreased Fat Oxidation Both in Resting and Aerobic Exercise in the Japanese MaleExperimental Diabetes Research, 2009
- Trends in overweight and obesity from 1985 to 2002 in Göteborg, West SwedenInternational Journal of Obesity, 2005
- Increased Risk of Obesity Resulting from the Interaction between High Energy Intake and the Trp64Arg Polymorphism of the β3-adrenergic Receptor Gene in Healthy Japanese MenJournal of Epidemiology, 2005
- Difficulty in losing weight by behavioral intervention for women with Trp64Arg polymorphism of the β3-adrenergic receptor geneInternational Journal of Obesity, 2003
- No association between body mass index and β3-adrenergic receptor variant (W64R) in children with premature pubarche and adolescent girls with hyperandrogenismFertility and Sterility, 2000
- The Trp64Arg mutation of the beta3 adrenergic receptor gene has no effect on obesity phenotypes in the Québec Family Study and Swedish Obese Subjects cohorts.JCI Insight, 1996
- An Adoption Study of Human ObesityThe New England Journal of Medicine, 1986