Expression of Restricted Immunoglobulin Isotypes in Plasmacellular Hyperplasia after Allogeneic Bone Marrow Transplantation
- 1 October 1987
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 26 (4), 409-416
- https://doi.org/10.1111/j.1365-3083.1987.tb02273.x
Abstract
Plasmacellular hyperplasia in lymphoid tissue was found in 4 out of 9 patients 1-6 months after allogeneic bone marrow transplantation as treatment for leukaemia. In the plasma cell populations, 13-85% expressed a single immunoglobulin light and heavy chain isotype (monotypic Ig expression). DNA analysis, using a DNA probe specific for heavy chain JH gene segments and for light chains, did not reveal the presence of clonally restricted B lymphocytes. The patients' sera lacked homogeneous immunoglobulins. We conclude that plasmacellular hyperplasia found after allogeneic bone marrow transplantation represents a polyclonal B-cell expansion- with a restriction in Ig isotype.Keywords
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