Skin condition associated with intensive use of alcoholic gels for hand disinfection: a combination of biophysical and sensorial data
- 11 May 2006
- journal article
- research article
- Published by Wiley in Contact Dermatitis
- Vol. 54 (5), 261-267
- https://doi.org/10.1111/j.0105-1873.2006.00817.x
Abstract
Although hand hygiene is an important and inexpensive measure to prevent nosocomial infections in clinical settings, the compliance of healthcare workers remains low. In Europe, alcoholic hand disinfection is first choice, but there exists a limited user acceptability due to estimated adverse effects on skin condition. This study was designed to investigate skin tolerance to alcohol-based disinfecting gels and changes in skin condition depending on humectant concentration, alcohol grades, as well as type of alcohol used. A comparison of 6 alcohol-based gels was made based on a randomized double-blind study under in use conditions for 1 day. Skin condition was evaluated by measuring transepidermal water loss (TEWL), stratum corneum hydration, apparent skin pH, redness and degree of scaliness. With respect to user acceptability, all gels were sensorially evaluated using a questionnaire. We saw that none of the alcohol-based gels, applied under in use conditions, altered TEWL or caused irritation. All gels hydrated the skin, proportionally to their glycerine content, and decreased skin pH. Elevated ethanol concentrations resulted in increased scaliness. Sensorial assessment revealed less appreciation for isopropanol. From this study, it was concluded that gels containing an elevated glycerine concentration and 70% (v/v) ethanol are preferred.Keywords
This publication has 31 references indexed in Scilit:
- Short‐term effects of alcohol‐based disinfectant and detergent on skin irritationContact Dermatitis, 2005
- Epidemiologic Background of Hand Hygiene and Evaluation of the Most Important Agents for Scrubs and RubsClinical Microbiology Reviews, 2004
- Introduction of a Waterless Alcohol-Based Hand Rub in a Long-Term–Care FacilityInfection Control & Hospital Epidemiology, 2003
- Squamometry as a screening method for the evaluation of hydrating productsSkin Research and Technology, 2001
- Generation of Free Fatty Acids from Phospholipids Regulates Stratum Corneum Acidification and IntegrityJournal of Investigative Dermatology, 2001
- Activity of an Alcohol-Based Hand Gel Against Human Adeno-, Rhino-, and Rotaviruses Using the Fingerpad MethodInfection Control & Hospital Epidemiology, 2000
- Disinfectants that doCurrent Opinion in Infectious Diseases, 2000
- Improving Compliance With Hand Hygiene in HospitalsInfection Control & Hospital Epidemiology, 2000
- The influence of cosmetic additives on the acceptability of alcohol-based hand disinfectantsJournal of Hospital Infection, 1991
- Guidelines for transepidermal water loss (TEWL) measurementContact Dermatitis, 1990