Ontogeny of amphetamine anorexia and insulin hyperphagia in the rat.

Abstract

Studied the effects of amphetamine and insulin on food intake in 1,438 sprague-dawley neonatal and weanling rats. Amphetamine did not produce anorexia prior to 15 days of age and insulin did not produce hyperphagia until 25 days of age. It is suggested that functional immaturity of the hypothalamus, a change in constituents monitored by the hypothalamus, or maturation of other structures may account for this developmental sequence. (22 ref.) (PsycINFO Database Record (c) 2006 APA, all rights reserved)