Temperature Induced Conformational Transitions of Elastin-Like Polypentapeptides Studied by Raman and NMR Spectroscopy

Abstract

Raman and NMR spectroscopy together with DFT quantum chemical calculations have been used to elucidate conformational changes occurring during inverse temperature transition in water solution of two elastin-like polypentapeptides, poly(G₁V₁G₂V₂P) and poly(AV₁GV₂P). From the temperature dependences of Raman spectra and¹H–¹H NOESY spectra follows that above the transition temperature aβ(II)-turn conformational structure is formed on the residue located between Pro and Val₁.