Nosocomial Bacteremia Caused by Antibiotic‐Resistant Gram‐Negative Bacteria in Critically Ill Patients: Clinical Outcome and Length of Hospitalization
Open Access
- 15 June 2002
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 34 (12), 1600-1606
- https://doi.org/10.1086/340616
Abstract
Population characteristics and outcomes were retrospectively compared for critically ill patients with nosocomial bacteremia caused by antibiotic-susceptible (AB-S; n = 208) or antibiotic-resistant (AB-R; n = 120) gram-negative bacteria. No significant differences in severity of illness and comorbidity factors were seen between groups. Patients with bacteremia caused by AB-R strains had a longer hospitalization before the onset of the bacteremia. The in-hospital mortality for patients with bacteremia caused by AB-S strains was 41.8%; for patients infected with AB-R strains, it was 45.0% (P = .576). A multivariate survival analysis demonstrated that older age (P = .009), a high-risk source of bacteremia (abdominal and lower respiratory tract; P = .031), and a high acute physiology and chronic health evaluation II-related expected mortality (P = .032) were independently associated with in-hospital mortality (P < .05). Antibiotic resistance in nosocomial bacteremia caused by gram-negative bacteria does not adversely affect the outcome for critically ill patients.Keywords
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