Squamous Cell Carcinoma of the Lung: Molecular Subtypes and Therapeutic Opportunities
Open Access
- 30 April 2012
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 18 (9), 2443-2451
- https://doi.org/10.1158/1078-0432.ccr-11-2370
Abstract
Lung cancer is the leading cause of cancer-related deaths worldwide. Next to adenocarcinoma, squamous cell carcinoma (SCC) of the lung is the most frequent histologic subtype in non–small cell lung cancer. Encouraging new treatments (i.e., bevacizumab, EGFR tyrosine kinase inhibitors, and ALK inhibitors) have afforded benefits to patients with adenocarcinoma, but unfortunately the same is not true for SCC. However, many genomic abnormalities are present in SCC, and there is growing evidence of their biologic significance. Thus, in the short term, the molecular characterization of patients with SCC in modern profiling platforms will probably be as important as deciphering the molecular genetics of adenocarcinoma. Patients with SCC of the lung harboring specific molecular defects that are actionable (e.g., fibroblast growth factor receptor 1 amplification, discoidin domain receptor 2 mutation, and phosphoinositide 3-kinase amplification) should be enrolled in prospective clinical trials targeting such molecular defects. Clin Cancer Res; 18(9); 2443–51. ©2012 AACR.Keywords
This publication has 83 references indexed in Scilit:
- Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent MannerCell, 2011
- Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer DevelopmentCell, 2011
- SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomasNature Genetics, 2009
- The cancer genomeNature, 2009
- Mutations in DDR2 Gene Cause SMED with Short Limbs and Abnormal CalcificationsAmerican Journal of Human Genetics, 2009
- Characterizing the cancer genome in lung adenocarcinomaNature, 2007
- A transforming mutation in the pleckstrin homology domain of AKT1 in cancerNature, 2007
- Impact of mutant p53 functional properties onTP53mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 databaseHuman Mutation, 2007
- High-throughput oncogene mutation profiling in human cancerNature Genetics, 2007
- Mutations of the BRAF gene in human cancerNature, 2002