Synthesis of nitric oxide from l-arginine by neutrophils. Release and interaction with superoxide anion
- 1 July 1989
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 261 (1), 293-296
- https://doi.org/10.1042/bj2610293
Abstract
Stimulated rat peritoneal neutrophils release a platelet inhibitory factor with the pharmacological properties of NO. This release is inhibited by NG-monomethyl-L-arginine and L-canavanine, indicating that it occurs through a mechanism similar to that in vascular endothelial cells and macrophages. As the degree of stimulation increases, the factor released is progressively inactivated by concomitant release of superoxide anions.Keywords
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