Primary Metastatic Neuroendocrine Small Cell Bladder Cancer: A Case Report and Literature Review
- 10 January 2012
- journal article
- case report
- Published by S. Karger AG in Urologia Internationalis
- Vol. 88 (3), 365-369
- https://doi.org/10.1159/000335141
Abstract
Small cell carcinoma of the urinary bladder (SCCUB) is a rare variant of neuroendocrine nonepithelial tumor. Clinically, SCCUB appears like a flat or ulcerated lesion and microscopically can cause microvascular invasion and necrosis. Small cell cancer, rarely found in the urogenital tract in a primitive form, usually coexists with urothelial bladder cancers. It has an incidence of 0.35–0.7% of all bladder neoplasms and survival at 5 years is estimated to be around 8%. A 60-year-old man who was a smoker was referred to our department with episodes of gross hematuria and pain in the lumbar region. After an extensive transurethral resection of the bladder, including of the muscular layer, the diagnosis of small cell carcinoma of the bladder was made. The neoplastic cells were positive with immunohistochemical staining for chromogranin A, paranuclear reactivity to cytokeratin and neuron-specific enolase. A total-body CT scan revealed lymph node involvement and hepatic, adrenal and lung metastases. Because of the advanced stage it was decided to avoid radical cystectomy and perform chemotherapy. The patient underwent two different cycles of cisplatin chemotherapy following international recommendations, but unfortunately without any response. After palliative therapy, the patient died in January 2010.Keywords
This publication has 22 references indexed in Scilit:
- Multidisciplinary approach in the treatment of patients with small cell bladder carcinomaEuropean Journal of Surgical Oncology, 2011
- A Surveillance, Epidemiology, and End Results analysis of small cell carcinoma of the bladderCancer, 2011
- Small cell carcinoma of the urinary bladder: a 15‐year retrospective review of treatment and survival in the Anglian Cancer NetworkBJU International, 2009
- Extrapulmonary Small Cell Carcinoma of the BladderSeminars in Oncology, 2007
- Small cell carcinoma of the urinary bladderCancer, 2005
- Morphology and therapeutic strategies for neuroendocrine tumors of the genitourinary tractCancer, 2002
- Small Cell Carcinoma of the Urinary BladderEuropean Urology, 2001
- Small cell carcinoma of the bladder and prostateUrology, 1995
- Chromosome abnormalities and p53 expression in a small cell carcinoma of the bladderCancer Genetics and Cytogenetics, 1995
- Small cell carcinoma of the urinary bladder. A clinicopathological study of six casesBritish Journal of Urology, 1994