The Metacarpal Index

Abstract
Early diagnosis of the Marfan syndrome may permit modification of the often lethal cardiovascular changes and alleviation of the more disabling ocular and musculoskeletal complications.1-3 Given the classical triad of long, thin, and loosely jointed bones, dislocation of the crystalline lens with tremulous irides, and dilatation of the ascending aorta with aortic valve insufficiency, the diagnosis of the Marfan syndrome is easily made, especially if relatives are known to have similar changes. But in cases where only equivocal features are present a firm diagnosis can be difficult, if not impossible, to make. The ocular and cardiovascular changes are highly suggestive of the Marfan syndrome; but it is the musculoskeletal involvement that most frequently brings the diagnosis to mind. Indeed, in the first cases reported, only the skeletal abnormalities were noted. Marfan, in 1896, described a five-year-old girl with unusually long, slender arms and legs whose long, thin fingers were