Serum Immunoglobulin Free Light Chain Assessment in IgG4-Related Disease
Open Access
- 26 June 2013
- journal article
- research article
- Published by Hindawi Limited in International Journal of Rheumatology
- Vol. 2013, 1-6
- https://doi.org/10.1155/2013/426759
Abstract
Immunoglobulin free light chains are produced in excess during normal antibody synthesis. Their evaluation is commonly used in case of a monoclonal gammopathy. In polyclonal hypergammaglobulinemia related to the Sjögren syndrome or systemic lupus, erythematosus serum free light chain levels are increased and could correlate with disease activity. We show here that theκ() andλ() free light chains and theκ : λratio () are increased in sixteen patients with IgG4-related disease when compared to healthy controls. The increase ofκandλfree light chains probably reflects the marked polyclonal B cell activation of the disease. We could not assess in this small cohort of patients a significative correlation of serum free light chain levels and disease activity or extension.Keywords
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