Office blood pressure variability as a predictor of acute myocardial infarction in elderly patients receiving antihypertensive therapy
- 1 February 2002
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Human Hypertension
- Vol. 16 (2), 141-146
- https://doi.org/10.1038/sj.jhh.1001301
Abstract
Larger variability of office blood pressure (BP) was reportedly associated with a higher risk of stroke or mortality from all causes. In the present study, we focused on the relationship of variability of office BP and occurrence of acute myocardial infarction (MI). We registered 139 patients receiving antihypertensive therapy for more than 1 year who experienced first-ever episode of MI at the age of 60 years or over. At least two sex- and age-matched (±5 years) control patients were registered for every MI patient. Average systolic and diastolic BP during the 12-month period prior to the occurrence of MI, or the time of registration in the case of control patients, was similar in both patient groups. The office BP variability was evaluated by calculating the variation coefficient (VC) of BP. VC of diastolic BP was significantly higher in the MI patients (10.0 ± 4.0%) compared with the control patients (8.8 ± 3.4%). VC of systolic BP was not different between the MI and the control patients. Multiple logistic analysis revealed the relationship of the VC for office diastolic BP to the occurrence of MI was significant after adjustment for BP level, age, gender, body mass index, serum total cholesterol concentrations, diabetes mellitus, and current smoking. In conclusion, larger long-term variability of office diastolic BP during antihypertensive therapy is a predictor of MI.Keywords
This publication has 10 references indexed in Scilit:
- Office blood pressure variability as a predictor of brain infarction in elderly hypertensive patients.Hypertension Research, 2000
- Blood pressure variability as an adverse prognostic risk factor in end-stage renal diseaseNephrology Dialysis Transplantation, 1999
- Risk factors of end-stage renal disease and serum creatinine in a community-based mass screeningKidney International, 1997
- Excessive circadian amplitude of blood pressure increases risk of ischaemic stroke and nephropathyJournal of Medical Engineering & Technology, 1997
- Nocturnal Blood Pressure and Silent Cerebrovascular Lesions in Elderly JapaneseStroke, 1996
- Nocturnal Fall of Blood Pressure and Silent Cerebrovascular Damage in Elderly Hypertensive PatientsHypertension, 1996
- Cardiac implications of the morning surge in blood pressure in elderly hypertensive patients: Relation to arising timeAmerican Journal of Hypertension, 1995
- Prognostic value of 24-hour blood pressure variabilityJournal Of Hypertension, 1993
- Trends and Determinants of Ischaemic Heart Disease Mortality in Finland: with Special Reference to a Possible Levelling off in the Early 1980sInternational Journal of Epidemiology, 1989
- Consequences of impaired arterial baroreflexes in essential hypertension: effects on pressor responses, plasma noradrenaline and blood pressure variabilityJournal Of Hypertension, 1988