Ginsenoside-Ra1 and ginsenoside-Ra2, new dammarane-saponins of ginseng roots.

Abstract

Two new dammarane-saponins, named ginsenoside-Ra₁ (1) and ginsenoside-Ra₂ (2) were isolated from the root of Panax ginseng C.A. MEYER by means of chromatography on silica gel and reversed phase chromatography on highly porous polymer. The structures of saponins 1 and 2 were established to be 20 (S)-protopanaxadiol 3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside-20-O-β-D-xylopyranosyl (1→4)-α-L-arabinopyranosyl (1→6)-β-D-glucopyranoside and 20 (S)-protopanaxadiol 3-O-β-D-glucopyranosyl (1→2)-β-D-glucopyranoside-20-O-β-D-xylopyranosyl (1→2)-α-L-arabinofuranosyl (1→6)-β-D-glucopyranoside, respectively.