Nanoparticle-based immunoassays in the biomedical field
- 1 January 2013
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 138 (4), 981-990
- https://doi.org/10.1039/c2an36500f
Abstract
Recent research has looked to develop innovative, powerful and novel biofunctionalized nanoparticles, controlling and tailoring their properties in a very predictable manner to meet the needs of clinic immunoassays in the biomedical field. This minireview briefly summarizes recent advances covering the last 3 years, exploiting nanoparticle-based electrochemical, optical, mass-sensitive, colorimetric and immunodipstick assays. The enormous signal enhancement associated with the use of nanoparticles and formation of nanoparticle–antibody–antigen assemblies provide the basis for sensitive detection of disease-related proteins or biomarkers. Rather than being exhaustive, this minireview focuses on selected examples to illustrate novel concepts and promising applications. Finally, a small amount of speculation of possible future developments in nanoparticle-based immunoassays is provided.This publication has 90 references indexed in Scilit:
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