Topical 5‐aminolaevulinic acid photodynamic therapy for intractable palmoplantar psoriasis
- 20 December 2006
- journal article
- case report
- Published by Wiley in The Journal of Dermatology
- Vol. 34 (1), 37-40
- https://doi.org/10.1111/j.1346-8138.2007.00213.x
Abstract
Photodynamic therapy (PDT) has been reported to be useful in treating non-melanoma skin cancers and a variety of benign skin conditions including psoriasis. However, only two reports of palmoplantar pustular psoriasis (PPP) treated with PDT have been reported. We treated three intractable cases of PPP with PDT, using 20% 5-aminolaevulinic acid and a 630+/-50 nm light-emitting diode device. The power density was 30 mW/cm2 and the fluence was 15 J/cm2. After treatment, all cases showed mild to marked improvement. Topical PDT may be an alternative therapy in the treatment of PPP, but further study is necessary to confirm the effectiveness of topical PDT in PPP.Keywords
This publication has 8 references indexed in Scilit:
- Recalcitrant palmoplantar pustular psoriasis successfully treated with topical 5-aminolaevulinic acid photodynamic therapyClinical and Experimental Dermatology, 2005
- Topical aminolaevulinic acid-based photodynamic therapy as a treatment option for psoriasis? Results of a randomized, observer-blinded studyBritish Journal of Dermatology, 2005
- Systemic Photodynamic Therapy with Aminolevulinic Acid Induces Apoptosis in Lesional T Lymphocytes of Psoriatic PlaquesJournal of Investigative Dermatology, 2002
- Topical photodynamic therapy at low fluence rates – theory and practiceJournal of Photochemistry and Photobiology B: Biology, 2001
- Topical photodynamic therapy using methylene blue and 5-aminolaevulinic acid in psoriasisJournal of Dermatological Treatment, 1997
- The Accumulation of Protoporphyrin IX in Plaque Psoriasis After Topical Application of 5-Aminolevulinic Acid Indicates a Potential for Superficial Photodynamic TherapyJournal of Investigative Dermatology, 1996
- Photodynamic therapy in psoriasis: suppression of cytokine production in vitro and recording of fluorescence modification during treatment in vivoArchiv für dermatologische Forschung, 1994