Prevalence of Thyroid Dysfunction in Turner's Syndrome: A Long-Term Follow-Up Study and Brief Literature Review
- 1 September 2005
- journal article
- research article
- Published by Mary Ann Liebert Inc in Thyroid®
- Vol. 15 (9), 1061-1066
- https://doi.org/10.1089/thy.2005.15.1061
Abstract
Thyroid dysfunction, especially hypothyroidism caused by Hashimoto's thyroiditis is more frequently observed in girls with Turner's syndrome (TS). The aim of the present study was to evaluate prevalence, etiology, karyotype distribution and age at onset of thyroid pathology in girls with TS. Data recorded in 84 girls with TS attending our clinic were analyzed. The mean age ± standard deviation [SD] at their initial evaluation was 10.3 ± 3.7 years (range, 0.5 to 19 years) and the mean period of observation was 8.4 ± 4.4 years. The thyroid function had been evaluated at least once per year in all patients and thyroid autoantibodies (ATA) were available in 51 (60.7%). Hypothyroidism was detected in 24% of the studied subjects and hyperthyroidism in 2.5%. Elevated values of thyroid autoantibodies were detected in 42% of girls with TS, whose ATA had been determined, and 65% had hypothyroidism. Thyroid dysfunction was first noted after the age of 8 years with no difference in the distribution of new cases at the different ages or pubertal stages. There was no difference in the incidence of thyroid dysfunction related to the type of karyotype abnormality. Thyroid dysfunction is more frequently encountered in girls with TS (hypothyroidism: 24% in the total group and 65% in those with positive ATA, hyperthyroidism: 2.5%). Thyroid dysfunction was observed after the age of 8 years with no difference in the occurrence of new cases in the various age groups thereafter. Hence, thyroid function should be evaluated yearly in girls with TS past the age of 8 years and more frequently in those with positive thyroid autoantibodies.Keywords
This publication has 37 references indexed in Scilit:
- Aspects of the treatment of Turner syndromeExpert Opinion on Pharmacotherapy, 2001
- The Sardinian Autoimmunity Study: 3. Studies on Circulating Antithyroid Antibodies in Sardinian Schoolchildren: Relationship to Goiter Prevalence and Thyroid FunctionThyroid®, 2001
- Subclinical Hypothyroidism: A Misnomer in Search of a New NameThyroid®, 2001
- Turner's Syndrome and Thyroid Disease: A Transverse Study of Pediatric Patients in BrazilJournal of Pediatric Endocrinology and Metabolism, 2000
- The incidence of thyroid disorders in the community: a twenty‐year follow‐up of the Whickham SurveyClinical Endocrinology, 1995
- Turner's syndrome with X‐isochromosome and Hashimoto's thyroiditisClinical Endocrinology, 1994
- Prevalence of Autoantibodies to Endocrine Organs in Girls with Ullrich-Turner Syndrome Aged 5-14 YearsHormone Research, 1992
- High incidence of thyroid disturbances in 49 children with Turner syndromeThe Journal of Pediatrics, 1987
- Organ-specific autoantibodies in children with common endocrine diseasesThe Journal of Pediatrics, 1982
- Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty.Archives of Disease in Childhood, 1976