Improved imaging of intrahepatic colorectal metastases with 18F-fluorodeoxyglucose respiratory-gated positron emission tomography
- 1 June 2012
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Nuclear Medicine Communications
- Vol. 33 (6), 656-662
- https://doi.org/10.1097/mnm.0b013e328351fce8
Abstract
In 18F-fluorodeoxyglucose PET/CT, respiratory motion induces bias in image interpretations (i.e. organ misregistration or lesion omission/underestimation). The present study applied our custom gating method (referred to as 'CT-based gated PET' and that has already been validated by our research group) to PET imaging of the liver and compared its per lesion sensitivity with that of standard clinical (i.e. ungated) PET. A total of 13 patients scheduled for liver surgery were referred to our department for PET/CT imaging. Each patient underwent both ungated and CT-based gated PET imaging protocols. Two independent, blinded observers interpreted the two sets of PET images and reached a consensus when necessary. Image interpretations were combined with histological analysis and/or intraoperative ultrasound examination to compute each method's per lesion sensitivity and true positive fraction. Analyses were also performed by considering lesions according to their size (longest axis over 10 mm or over 15 mm). Forty-eight lesions were confirmed by pathology reports. When considering all the uptakes, the ungated and the CT-based gated PET methods had sensitivities of 54.2 and 64.6% (P=0.025) and true positive fractions of 83.9 and 86.1%, respectively. When considering uptakes greater than 10 mm in size, ungated and CT-based gated PET had sensitivities of 74.3 and 88.6% (P=0.025), respectively. For lesions greater than 15 mm in size, the corresponding sensitivities were 85.2 and 100% (P=0.046). CT-based gated PET yielded a higher lesion-based sensitivity than routine, ungated PET did. Hence, this method improves the detection of intrahepatic colorectal metastases--especially for lesions that are close in size to the detection limit of the PET gantry.Keywords
This publication has 29 references indexed in Scilit:
- Performance of imaging modalities in diagnosis of liver metastases from colorectal cancer: A systematic review and meta‐analysisJournal of Magnetic Resonance Imaging, 2009
- Improved Selection of Patients for Hepatic Surgery of Colorectal Liver Metastases with 18F-FDG PET: A Randomized StudyJournal of Nuclear Medicine, 2009
- Usefulness of a deep-inspiration breath-hold 18F-FDG PET/CT technique in diagnosing liver, bile duct, and pancreas tumorsNuclear Medicine Communications, 2009
- Evaluation of Image Registration in PET/CT of the Liver and Recommendations for Optimized ImagingJournal of Nuclear Medicine, 2007
- The Role and Limitations of 18-Fluoro-2-deoxy-d-glucose Positron Emission Tomography (FDG-PET) Scan and Computerized Tomography (CT) in Restaging Patients with Hepatic Colorectal Metastases Following Neoadjuvant Chemotherapy: Comparison with Operative and Pathological FindingsJournal of Gastrointestinal Surgery, 2007
- A motion-incorporated reconstruction method for gated PET studiesPhysics in Medicine & Biology, 2006
- Model‐based image reconstruction for four‐dimensional PETMedical Physics, 2006
- Value of Positron Emission Tomography With [F-18]Fluorodeoxyglucose in Patients With Colorectal Liver Metastases: A Prospective StudyJournal of Clinical Oncology, 2002
- Fast reconstruction of 3D PET data with accurate statistical modelingIEEE Transactions on Nuclear Science, 1998
- Quantitation in Positron Emission Computed TomographyJournal of Computer Assisted Tomography, 1982