Quantitative Trait Loci (QTL) Detection in Multicross Inbred Designs
Open Access
- 1 November 2004
- journal article
- research article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 168 (3), 1737-1749
- https://doi.org/10.1534/genetics.104.028993
Abstract
Mapping quantitative trait loci in plants is usually conducted using a population derived from a cross between two inbred lines. The power of such QTL detection and the parameter estimates depend largely on the choice of the two parental lines. Thus, the QTL detected in such populations represent only a small part of the genetic architecture of the trait. In addition, the effects of only two alleles are characterized, which is of limited interest to the breeder, while common pedigree breeding material remains unexploited for QTL mapping. In this study, we extend QTL mapping methodology to a generalized framework, based on a two-step IBD variance component approach, applicable to any type of breeding population obtained from inbred parents. We then investigate with simulated data mimicking conventional breeding programs the influence of different estimates of the IBD values on the power of QTL detection. The proposed method would provide an alternative to the development of specifically designed recombinant populations, by utilizing the genetic variation actually managed by plant breeders. The use of these detected QTL in assisting breeding would thus be facilitated.Keywords
This publication has 19 references indexed in Scilit:
- Multipoint Estimation of Identity-by-Descent Probabilities at Arbitrary Positions among Marker Loci on General PedigreesHuman Heredity, 2001
- Economic Efficiency of One Cycle of Marker-Assisted SelectionCrop Science, 2000
- Mapping linked quantitative trait loci via residual maximum likelihoodGenetics Selection Evolution, 1997
- Markov Chain Monte Carlo Segregation and Linkage Analysis for Oligogenic ModelsAmerican Journal of Human Genetics, 1997
- Mapping quantitative trait loci in outcross populations via residual maximum likelihood. II. A simulation studyGenetics Selection Evolution, 1996
- Power of tests for quantitative trait loci detection using full-sib families in different schemesHeredity, 1996
- Simulation of marker assisted selection in hybrid populationsGenetics Research, 1994
- A simple regression method for mapping quantitative trait loci in line crosses using flanking markersHeredity, 1992
- Diversity and Relationships among U.S. Maize Inbreds Revealed by Restriction Fragment Length PolymorphismsCrop Science, 1991
- Mathematical model for studying genetic variation in terms of restriction endonucleases.Proceedings of the National Academy of Sciences of the United States of America, 1979