CHD4 in the DNA-damage response and cell cycle progression: not so NuRDy now
Open Access
- 23 May 2013
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 41 (3), 777-782
- https://doi.org/10.1042/bst20130027
Abstract
The CHD4 (chromodomain-helicase-DNA-binding 4) (or Mi-2β) protein is a founding component of the NuRD (nucleosome remodelling and deacetylation) complex. NuRD has long been known to function in transcriptional regulation, and is conserved throughout the animal and plant kingdoms. In recent years, evidence has steadily accumulated indicating that CHD4 can both function outside of the NuRD complex and also play important roles in cellular processes other than transcriptional regulation. A number of loss-of-function studies have identified important roles for CHD4 in the DNA-damage response and in cell cycle progression through S-phase and into G2. Furthermore, as part of NuRD, it participates in regulating acetylation levels of p53, thereby indirectly regulating the G1/S cell cycle checkpoint. Although CHD4 has a somewhat complicated relationship with the cell cycle, recent evidence indicates that CHD4 may exert some tumour-suppressor functions in human carcinogenesis. CHD4 is a defining member of the NuRD complex, but evidence is accumulating that CHD4 also plays important NuRD-independent roles in the DNA-damage response and cell cycle progression, as well as in transcriptional regulation.Keywords
This publication has 58 references indexed in Scilit:
- Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genesNature Genetics, 2012
- The PHD and Chromo Domains Regulate the ATPase Activity of the Human Chromatin Remodeler CHD4Journal of Molecular Biology, 2012
- Concerted action of the PHD, chromo and motor domains regulates the human chromatin remodelling ATPase CHD4FEBS Letters, 2012
- NuRD Suppresses Pluripotency Gene Expression to Promote Transcriptional Heterogeneity and Lineage CommitmentCell Stem Cell, 2012
- A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structureThe EMBO Journal, 2012
- Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4The EMBO Journal, 2010
- Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modificationsBiochemical Journal, 2009
- Ageing-related chromatin defects through loss of the NURD complexNature, 2009
- Keeping things quiet: Roles of NuRD and Sin3 co-repressor complexes during mammalian developmentThe International Journal of Biochemistry & Cell Biology, 2009
- ATP-dependent chromatin remodeling factors and DNA damage repairMutation research. Reviews in mutation research, 2007