Cholinergic effects on human gastric motility
Open Access
- 1 September 1999
- Vol. 45 (3), 346-354
- https://doi.org/10.1136/gut.45.3.346
Abstract
BACKGROUNDCholinergic regulation of chronotropic (frequency) and inotropic (force) aspects of antral contractility and how these impact on gastric emptying are not well delineated.AIMSTo determine the effects of cholinergic stimulation and inhibition on myoelectric, contractile, and emptying parameters of gastric motility.METHODSTen normal subjects underwent three studies each, using simultaneous electrogastrography (EGG), antroduodenal manometry, and gastric emptying with dynamic antral scintigraphy (DAS). After 30 minutes of baseline fasting manometry and EGG, subjects received saline intravenously, atropine (0.6 mg then 0.25 mg/hour intravenously), or bethanechol (5 mg subcutaneously). This was followed by another 30 minutes’ recording and by three hours of postprandial recording after ingestion of a technetium-99m labelled solid meal.RESULTSDuring fasting, atropine decreased, whereas bethanechol increased, the antral manometric motility index and EGG power. Postprandially, atropine decreased the amplitude of antral contractions by DAS, decreased the postprandial antral manometric motility index, and slowed gastric emptying. Atropine caused a slight increase in postprandial frequency of antral contractions by DAS and gastric myoelectrical activity by EGG. Bethanechol slightly increased the amplitude, but slightly decreased the frequency of antral contractions by DAS and decreased the frequency of gastric myoelectrical activity by EGG, with no significant increase in the motility index or gastric emptying.CONCLUSIONSCholinergic antagonism with atropine reduces antral contractility and slows gastric emptying. Cholinergic stimulation with bethanechol increases antral contractility, but decreases the frequency of antral contractions, without altering the antral motility index or gastric emptying.Keywords
This publication has 26 references indexed in Scilit:
- Effect of gastric acid suppressants on human gastric motilityGut, 1998
- An evaluation of an ambulatory manometry system in assessment of antroduodenal motor activityDigestive Diseases and Sciences, 1996
- Recent advances in gastric emptying scintigraphySeminars in Nuclear Medicine, 1995
- Gastrointestinal motor and secretory responses to cholinergic stimulation in humans. Differential modulation by muscarinic and cholecystokinin receptor blockadeEuropean Journal of Clinical Investigation, 1995
- Effect of intravenous atropine on gastric emptying, paracetamol absorption, salivary flow and heart rate in young and fit elderly volunteers.British Journal of Clinical Pharmacology, 1990
- The two-component stomach: effects of meal particle size on fundal and antral emptyingEuropean Journal of Nuclear Medicine and Molecular Imaging, 1989
- Biphasic nature of gastric emptying.Gut, 1988
- Relationship between impaired gastric emptying and abnormal gastrointestinal motilityGastroenterology, 1986
- Cholinergic effects on gallbladder emptying in humansGastroenterology, 1985
- Continuous monitoring of the effect of pentagastrin on gastric emptying of solid food in man.Gut, 1976