Type III Secretion: a Virulence Factor Delivery System Essential for the Pathogenicity of Burkholderia mallei
- 1 February 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (2), 1150-4
- https://doi.org/10.1128/iai.72.2.1150-1154.2004
Abstract
By creating mutations in the Burkholderia mallei ATCC 23344 animal pathogen-like type III secretion system (TTSS), this study analyzes the correlation between type III secretion and the pathogenicity of ATCC 23344 in vivo. Mutagenesis demonstrated that a functional TTSS was required for the full pathogenicity of ATCC 23344 in the BALB/c mouse and Syrian hamster models of infection. However, vaccination with each mutant failed to elicit a protective immunity against challenge with wild-type ATCC 23344.Keywords
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