Evolutionary Origins of the Fumonisin Secondary Metabolite Gene Cluster inFusarium verticillioidesandAspergillus niger
Open Access
- 23 May 2011
- journal article
- Published by Hindawi Limited in International Journal of Evolutionary Biology
- Vol. 2011, 1-7
- https://doi.org/10.4061/2011/423821
Abstract
The secondary metabolite gene clusters of euascomycete fungi are among the largest known clusters of functionally related genes in eukaryotes. Most of these clusters are species specific or genus specific, and little is known about how they are formed during evolution. We used a comparative genomics approach to study the evolutionary origins of a secondary metabolite cluster that synthesizes a polyketide derivative, namely, the fumonisin (FUM) cluster ofFusarium verticillioides, and that ofAspergillus nigeranother fumonisin (fumonisin B) producing species. We identified homologs in other euascomycetes of theFusarium verticillioides FUMgenes and their flanking genes. We discuss four models for the origin of theFUMcluster inFusarium verticillioidesand argue that two of these are plausible: (i) assembly by relocation of initially scattered genes in a recentFusarium verticillioides; or (ii) horizontal transfer of theFUMcluster from a distantly related Sordariomycete species. We also propose that theFUMcluster was horizontally transferred intoAspergillus niger, most probably from a Sordariomycete species.Keywords
This publication has 34 references indexed in Scilit:
- Horizontal Transfer of a Large and Highly Toxic Secondary Metabolic Gene Cluster between FungiCurrent Biology, 2011
- SMURF: Genomic mapping of fungal secondary metabolite clustersFungal Genetics and Biology, 2010
- Evidence for horizontal transfer of a secondary metabolite gene cluster between fungiGenome Biology, 2008
- Origin and distribution of epipolythiodioxopiperazine (ETP) gene clusters in filamentous ascomycetesBMC Evolutionary Biology, 2007
- The Fusarium verticillioides FUM Gene Cluster Encodes a Zn(II)2Cys6 Protein That Affects FUM Gene Expression and Fumonisin ProductionEukaryotic Cell, 2007
- Aspergillus nigergenomics: Past, present and into the futureMedical Mycology, 2006
- Birth of a metabolic gene cluster in yeast by adaptive gene relocationNature Genetics, 2005
- The genome sequence of the rice blast fungus Magnaporthe griseaNature, 2005
- The genome sequence of the filamentous fungus Neurospora crassaNature, 2003
- CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceNucleic Acids Research, 1994