Esophageal obstruction in the newborn is most frequently related to an atretic segment, which is usually associated with a tracheo-esophageal fistula. Rarely, an intraluminal membrane serves as the etiologic factor for esophageal obstruction. The recent successful treatment of such a case prompted a review of the literature and this report. Report of a Case This infant was admitted to The Strong Memorial Hospital as a 1-day-old female with a diagnosis of esophageal atresia. She had been born 28 hours prior to admission. The pregnancy had been uncomplicated, and delivery was normal and spontaneous. The baby weighed 5 lb. 13 oz. (712 gm.) at birth, and a cleft palate had been noted. It is of interest that 5 of the 6 siblings of the patient had cleft palates. Another sibling died at age 2 weeks due to "intestinal obstruction." Both parents are well, and neither has cleft lip or palate. On