Mouse Leukemia: Therapy with Monoclonal Antibodies Against a Thymus Differentiation Antigen
- 4 January 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 207 (4426), 68-71
- https://doi.org/10.1126/science.6965328
Abstract
Monoclonal antibodies against a thymus cell differentiation antigen (Thy-1.1) were effective in the therapy of a transplanted mouse leukemia. Passive immunization resulted in high titers of cytotoxic antibody in the serum of treated mice and the suppression of metastatic tumor cells. The tumor-suppressive effects of the monoclonal antibodies were amplified by the administration of exogenous complement. This combined antibody and complement therapy resulted in the cure of leukemia in a significant proportion of the treated animals.Keywords
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