P450 SUBFAMILY CYP2J AND THEIR ROLE IN THE BIOACTIVATION OF ARACHIDONIC ACID IN EXTRAHEPATIC TISSUES*
Open Access
- 1 January 1999
- journal article
- review article
- Published by Informa UK Limited in Drug Metabolism Reviews
- Vol. 31 (1), 205-234
- https://doi.org/10.1081/dmr-100101915
Abstract
Historically, there has been intense interest in P450 metabolic oxidation, peroxidation, and reduction of xenobiotics. More recently, there has been a growing appreciation for the role of P450s in the oxidation of lipophilic endobiotics, such as bile acids, fat-soluble vitamins, and eicosanoids. This review details the emerging CYP2J subfamily of P450s and their role as catalysts of arachidonic acid metabolism.Keywords
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