Same-Day Imaging Using Small Proteins: Clinical Experience and Translational Prospects in Oncology
Top Cited Papers
Open Access
- 1 June 2018
- journal article
- research article
- Published by Society of Nuclear Medicine in Journal Of Nuclear Medicine
- Vol. 59 (6), 885-891
- https://doi.org/10.2967/jnumed.117.199901
Abstract
Imaging of expression of therapeutic targets may enable stratification of patients for targeted treatments. The use of small radiolabeled probes based on the heavy-chain variable region of heavy-chain-only immunoglobulins or nonimmunoglobulin scaffolds permits rapid localization of radiotracers in tumors and rapid clearance from normal tissues. This makes high-contrast imaging possible on the day of injection. This mini review focuses on small proteins for radionuclide-based imaging that would allow same-day imaging, with the emphasis on clinical applications and promising preclinical developments within the field of oncology.Keywords
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