Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal
- 14 May 2008
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 453 (7193), 306-313
- https://doi.org/10.1038/nature07038
Abstract
When stem cells divide, they can generate progeny with the same developmental potential as the original cell, a process referred to as self-renewal. Self-renewal is driven intrinsically by gene expression in a cell-type-specific manner and is modulated through interactions with extrinsic cues from the environment, such as growth factors. However, despite the prevalence of the term self-renewal in the scientific literature, this process has not been defined at the molecular level. Haematopoietic stem cells are an excellent model for the study of self-renewal because they can be isolated prospectively, manipulated relatively easily and assessed by using well-defined assays. Establishing the principles of self-renewal in haematopoietic stem cells will lead to insights into the mechanisms of self-renewal in other tissues.Keywords
This publication has 100 references indexed in Scilit:
- Hematopoiesis: An Evolving Paradigm for Stem Cell BiologyCell, 2008
- Cancer stem cells in solid tumorsCurrent Opinion in Biotechnology, 2007
- HOX Gene Regulation in Acute Myeloid Leukemia: CDX Marks the Spot?Cell Cycle, 2007
- Asymmetric cell division within the human hematopoietic stem and progenitor cell compartment: identification of asymmetrically segregating proteinsBlood, 2007
- Male and Female Drosophila Germline Stem Cells: Two Versions of ImmortalityScience, 2007
- Asymmetric Inheritance of Mother Versus Daughter Centrosome in Stem Cell DivisionScience, 2007
- Neural stem cells in mammalian developmentCurrent Opinion in Cell Biology, 2006
- SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purityBlood, 2006
- Self-Renewal of the Adult Skeletal Muscle Satellite CellCell Cycle, 2005
- Asymmetric Division and Lineage Commitment at the Level of Hematopoietic Stem CellsThe Journal of Experimental Medicine, 2004