Cyclin E in normal and neoplastic cell cycles
Open Access
- 18 April 2005
- journal article
- review article
- Published by Springer Science and Business Media LLC in Oncogene
- Vol. 24 (17), 2776-2786
- https://doi.org/10.1038/sj.onc.1208613
Abstract
Cyclin E-Cdk2 has long been considered an essential and master regulator of progression through G1 phase of the cell cycle. Although recent mouse models have prompted a rethinking of cyclin E function in mammals, it remains clear that cyclin E impacts upon many processes central to cell division. Normal cells maintain strict control of cyclin E activity, and this is commonly disrupted in cancer cells. Moreover, cyclin E deregulation is thought to play a fundamental role in tumorigenesis. In this review, we discuss the regulation and functions of cyclin E in normal and neoplastic mammalian cells.Keywords
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